Pirkle-type Chiral Columns

Exclusively from Regis Technologies

In 1980, Regis Technologies along with Professor William Pirkle of the University of Illinois, introduced the Pirkle Chiral Stationary Phase (CSP). Today Regis manufactures nine Pirkle CSPs in analytical and preparative sizes and in bulk material.

Products

Wide Range of Enantiomer Separations

Pirkle CSPs separate a wide variety of compound groups including: Aryl Propionic, Acid Non-Sterodial, Anti-Inflammatory Drugs (NSAIDs), ß-Blockers and many other pharmaceuticals.
See the Chiral Application Guide 6 for examples of enantiomer separations.

Excellent Column Durability

Covalent phase bonding of Pirkle columns are long-lasting, unlike their coated preparative column counterparts where non-covalent coatings can leach off.
Covalent bonding enables their use as preparative columns.
Columns have capacity to tolerate sample overload.

Ability to Invert Elution Order

By using Pirkle CSPs in the opposite absolute configuration, you can invert the elution order so that trace enantiomers elute before the major ones. This feature is extremely desirable for enantiomeric purity determinations.

Analytical and Preparative Columns, and Bulk Material

Manufactured on-site, we can pack special or custom-sized columns quickly and easily.

Universal Solvent Compatibility

Compatible with most mobile phases with at pH 2.5 to 7.5.
Use in both normal-phase and reversed-phase modes.
The classic mobile phase for normal-phase separations is a binary or ternary mixture of a hydrocarbon and a modifier, usually an aliphatic alcohol.
Typical uncharged organic modifiers include ethanol, isopropanol and butanol.
Under reversed-phase conditions, water-alcohol mixtures, or aqueous phosphate buffers with charged organic modifiers can also be employed.
The separation of enantiomers on Pirkle CSPs using super critical fluid chromatography (SFC), which utilizes carbon dioxide, is now proven.