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Fluorinated Anhydrides: TFAA

TFAA is an Acylation Reagent for GC Derivatization that is most commonly used for ECD and reacts with alcholos, amines, and phenols.  Bases such as triethylamine and trimethylamine can be added to promote reactivity to TFAA.  TFAA is frequently used for the confirmation of drugs of abuse.

TFAA is the most reactive and volatile of the anhydrides.

Physical and Chemical Properties
    Suggested Storage Conditions:    Cool Place
    Use:    Acylation Reagent for GC
    Appearance:    Clear, colorless liquid
    BP:    39.5-40ºC (103ºF)
    MW:    C4F6O3
    FW:    210.03 g/mol
    Specific Gravity (H2O = 1.0):    1.487

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Fluorinated Anhydrides:    TFAA; Trifluoroacetic Anhydride
CAS [407-25-0]
ProductSizeRegis
Product #
U.S. Price
TFAA10x1 gram270841$67.28
TFAA25 gram270843$31.05