Regis Technologies was originally located in downtown Chicago, but moved to Morton Grove in 1973. Since then, we have maintained a policy of regular reinvestment to keep our facilities up-to-date and increase our capabilities to better serve our customers needs.

Take a virtual tour of our facilities through the photo gallery below. If you want to learn more, schedule a visit.

Follow along the material flow through Regis. We begin at the dock where raw materials are received. Click on the picture to read about the area.

PRODUCTION

SYNTHETIC LABS

Regis Technologies executes all chemistry at pilot scale before scale-up. This allows our chemists to obtain proof of principle and gain experience with a given set of reactions prior to scale-up. Small scale R&D and changes to procedures are examined on this level prior to scale-up.

PRODUCTION

KILO-SCALE LABS

The kilo lab can be either the starting point for a project, or the permanent residence for a low-volume project. Our design assures complete compliance with cGMP guidelines, offers maximum protection against cross contamination, and allows chemists to handle hazardous materials with confidence. The facility is divided into three completely enclosed suites, each containing a hood and workspace. Incoming air is purified via 99.99% HEPA filters, and the individual rooms are maintained at a positive pressure relative to the corridor.

PRODUCTION

GLASS REACTOR SUITE

The suite contains two 63 liter glass reactor systems. These systems feature insulated, glass lined steel jacketed bodies and all glass domes with attached reflux and stripping condensers. The robust variable speed agitation systems are comprised of Teflon lined stainless steel shafts with all Teflon anchor type stirring blades. The reactors utilize single fluid heating/cooling with a temperature range of -20°C to 120°C.

PRODUCTION

500 GALLON REACTOR SUITE

Regis currently has seven fully equipped reactor suites with Reactor sizes ranging from 50 to 500 gallons. Each two-floor suite contains a pair of Pfaudler glass-lined reactors, with starting materials loaded on the second floor, and a centrifuge for work-up on the ground floor. Additional equipment, such as portable tanks and filter presses, can be moved in as needed. These reactor suites also are capable of low-pressure (less than 80 psi) hydrogenation.

Regis’ Reactor Suites are designed as individual manufacturing areas, thereby reducing the chance of cross contamination.

PRODUCTION

CRYOGENIC REACTOR SUITE

Regis’ cryogenic reactor suite contains a 150-gallon Hastelloy reactor. This vessel is used for enantioselective, site-specific additions and other low temperature reactions, including lithiations. The reactor has a range of -85°C to 100°C.

PRODUCTION

PRODUCT ISOLATION

A centrifuge is typically used for isolating products or intermediates. All centrifuges are made of 316 stainless steel.

Polypropylene and 316 stainless steel filter presses are also available.

PRODUCTION

TEMPERATURE MONITOR

Chemists and technicians manually enter all critical temperatures into batch records. In addition, temperatures for all production equipment and refrigerators/freezers are continuously monitored via a data logging system.

PRODUCTION

CLEANED EQUIPMENT STORAGE

All ancillary equipment is cleaned in a separate washing room before being moved to this room.

FINISHING

FINISHING

Isolated products are transferred to a finishing room for drying, grinding, and packaging. Because contamination is a particular concern at this point, access to this area is strictly controlled. The hallway is maintained at a positive pressure relative to the entire facility, including the drying rooms. Each of the five drying rooms has its own supply of 99.99% HEPA-filtered air, now class 100,000 certified.

FINISHING

DRYING EQUIPMENT

A variety of drying equipment is available, including three sizes of Stokes and United-McGill ovens. Our drying/finishing area is class 100,000.

FINISHING

LYOPHILIZER

Regis maintains one finishing room with Virtis 6 liter and 45 liter capacity lyophilizers. This allows recovery of products from water in an area with class 100,000 air.

QUALITY CONTROL

QUALITY CONTROL

Our fully equipped QC lab operates in two shifts, as does our production team. Most required analytical work can be performed in-house, ensuring rapid turnaround for our clients. Major equipment includes: seven Agilent 1100 HPLCs, one Agilent 1100 LC/MS, three Agilent 1200 HPLCs, three Agilent 6890 GCs, a P-E elemental analyzer, a P-E FTIR, a Malvern Particle size analyzer, and a Hitachi spectrophotometer.

HAVE A CHEMISTRY NEED? REQUEST A QUOTE.