Chirality plays a very important role in the development of new drugs. Chirality also plays an important role in flavor and fragrance chemistry. For example, menthol is a terpenoid alcohol with eight possible stereoisomers. It has been found that the (-)-menthol enantiomer possesses the intense cooling and clean, notable minty odor. The (+)-menthol enantiomer is less cooling and possesses a musty odor. This musty odor is also present in the racemic form of menthol. For this reason it is important that food chemists have individual isomers on hand to perform further studies on the beneficial or non-beneficial properties of the individual isomers.

We will perform several experiments on Linalool and Terpinen-4-ol (both naturally occurring terpenes) on a RegisPack chiral stationary phase and evaluate its ability to resolve the racemates and perform a small scale SFC purification to isolate the individual isomers for further studies.

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