Pidgeon and Venkataran1 patented a method for immobilizing phospholipids on HPLC-grade silica stationary phases. The immobilized phospholipids mimic the lipid environment of a fluid cell membrane on a solid matrix. Regis Technologies offers various IAM HPLC stationary phases that are prepared by covalently bonding the phospholipids to amino-propyl silica phases. The remaining amino-propyl groups and the free silanol groups are treated to reduce their secondary interactions with the compounds. The IAM stationary phase contains covalently bonded phosphatidyl choline covering the silica particles at monolayer density.
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