RAM Semi-Permeable Surface (SPS)
Restricted Access Media (RAM) Direct Injection columns separate small molecules in the presence of much larger analytes without extensive sample pretreatment. Therefore, complex sample matrices can be directly injected without prior sample clean-up for the separation and detection of drugs, drug metabolites, peptides and other analytes.
The inner and outer surfaces of the Semi-Permeable Surface (SPS) are bonded separately, allowing each to be varied independently. Available inner surface phase chemistries include ODS, Octyl, and Phenyl, which allow for retention of small molecule analytes. The hydrophilic outer phase of polyethylene glycol provides size exclusion and hydrophilic shielding to repel large biomolecules.
Lower cost and save time by adopting the RAM HPLC alternative to analyze small molecules.