Derivatization is primarily performed to modify an analyte's functionality to enable chromatographic separations. For more than 50 years, Regis has been a leader in the manufacture of highly pure derivatization reagents for gas chromatography. The formation of chemical derivatives to facilitate meaningful analysis has long been a common practice in gas chromatography. For the analytical chemist, judicious use of derivatization can be the key to unlocking and simplifying a great many complex and perplexing separation problems. Derivatization, accomplished through alteration of functional groups, provides:

  • Increased sample volatility
  • Improved selectivity and chromatographic efficiency
  • Enhanced detectability

Sample volatility or thermal stability is crucial in GC applications. If a sample does not possess these important characteristics, GC analysis is highly unproductive. Derivatization techniques have been developed to address these issues to ensure successful separations. In GC Derivatization, replacement of active hydrogen in functional groups, such as -COOH, -OH, -NH, and -SH, is the primary area of concern and is accomplished through silylation, acylation, or alkylation.

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Download GC Derivatization Reagent Procedures.

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