Whelk-O® 2

Category: Pirkle-type Chiral Columns

The Whelk-O 2 is the covalent trifunctional version of the Whelk-O 1. The Whelk-O 2 retains the same chiral selector but incorporates a trifunctional linkage to the silica support. In most cases, the enantioselectivity remains the same as that obtained with the Whelk-O 1. Whelk-O 2 was designed to improve the resistance of the stationary phase to hydrolysis while using strong organic modifiers such as trifluoroacetic acid. The Whelk-O 2 is ideal for preparative separations since the material is bonded on 10 µm, 100Å spherical Kromasil silica. This allows the preparative chromatographer to perform method development on an analytical column and immediately scale up to larger diameter columns.

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Selector:  1-(3,5-dinitrobenzamido)-1,2,3,4-tetrahydrophenanthrene
Techniques: High-Performance Liquid Chromatography (HPLC) & Supercritical Fluid Chromatography (SFC)